(Organic Complex Anti-aging)

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1 (Organic Complex Anti-aging)
유기농 콤플렉스 안티에이징 (Organic Complex Anti-aging) 유기농 콤플렉스 안티에이징은 피부 노화에 따라 기능이 저하된 세포를 활성화하고, 콜라겐과 엘라스틴의 생성을 촉진해 피부 탄력을 유지 하고 주름생성 억제 효과를 줍니다 주요 성분 성분명 성분 효능 병풀추출물 콜라겐을 생성, elastin을 파괴하는 효소인 elastase의 활성을 억제 함(ref 1.1~1.2) 바위돌꽃뿌리추출물 콜라겐생성을 억제시키는 MMP의 활성을 저해(ref 1.3)하고, 항산화 효능(ref 1.4) 님잎추출물 항산화 효능(ref 1.5~1.8) 성모초잎추출물 파파야잎추출물 항산화 효능(ref 1.5~1.8), 피부 상처 치유 및 재생효능이 뛰어남(ref 1.9, 1.10)

2 (Organic Complex Anti-aging)
유기농 콤플렉스 안티에이징 (Organic Complex Anti-aging) 신규 콤플렉스 소개서_Anti-aging INCI 명 Water, Glycerin, Centella Asiatica Extract, Rhodiola Rosea Root Extract, Azadirachta Indica Leaf Extract, Alchemilla Vulgaris Extract, Carica Papaya (Papaya) Leaf Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata (Lichen) Extract 효능 (a)유기농 콤플렉스 안티에이징 처리에 의한 세포독성 확인 결과 0.005% 0.016% 0.05% 0.005% 0.016% 0.05% (b)유기농 콤플렉스 안티에이징 처리에 의한 MMP-1발현 확인 결과 인간 피부섬유아세포에 유기농 콤플렉스 안티에이징을 처리한 결과, 독성을 나타내지 않음을 확인함(a) 유기농 콤플렉스 안티에이징은 주름생성에 영향을 미치는 MMP-1의 발현을 농도 의존적으로 억제함(b) 이러한 결과를 통하여 유기농 콤플렉스 안티에이징은 생성된 주름을 개선하는 효능이 있음을 확인함

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유기농 콤플렉스 안티에이징 (Organic Complex Anti-aging) References Anti-aging Effects. 1.1 Hashim P. Pak J Pharm Sci Mar;27(2):233-7. 1.2 Nema NK, Maity N, Sarkar BK, Mukherjee PK. Pharm Biol Sep;51(9): 1.3 Lee TH, Hsu CC, Hsiao G, Fang JY, Liu WM, Lee CK. Planta Med May;82(8): 1.4 Calcabrini C, De Bellis R, Mancini U, Cucchiarini L, Potenza L, De Sanctis R, Patrone V, Scesa C, Dachà M. Arch Dermatol Res. 2010 Apr;302(3): 1.5. Tupe RS, Sankhe NM, Shaikh SA, Phatak DV, Parikh JU, Khaire AA, Kemse NG. J Food Sci Technol Apr;52(4): 1.6. Oktyabrsky O, Vysochina G, Muzyka N, Samoilova Z, Kukushkina T, Smirnova G. J Appl Microbiol Apr;106(4): 1.7 Kokila T, Ramesh PS, Geetha D. Biosynthesis of AgNPs using Carica Papaya peel extract and evaluation of its antioxidant and antimicrobial activities. Ecotoxicol Environ Saf May 3. pii: S (16) 1.8 Ghimeray AK, Jung US, Lee HY, Kim YH, Ryu EK, Chang MS. In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract. Clin Cosmet Investig Dermatol Jul 16;8:389-96 1.9 Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacol Physiol. 2014;27(6): 1.10 Nayak BS, Ramdeen R, Adogwa A, Ramsubhag A, Marshall JR. Wound-healing potential of an ethanol extract of Carica papaya (Caricaceae) seeds. Int Wound J Dec;9(6):650-5.

4 (Organic Complex Whitening)
유기농 콤플렉스 화이트닝 (Organic Complex Whitening) 유기농 콤플렉스 화이트닝은 피부의 기미, 주근깨 및 피부 색소 침착의 원인이 되는 멜라닌 생성을 억제하여 피부가 칙칙해지는 것을 방지하고 피부 톤을 밝고 환하게 가꿔 줍니다 주요 성분 성분명 성분 효능 님잎추출물 멜라닌생성을 촉진하는데 가장 크게 영향을 미치는 Tyrosinase효소의 활성을 억제(ref 2.1) 감초추출물 식약처 미백 고시 원료 중 하나로 천연물 소재 중 미백 화장품 소재로 현재 가장 많이 사용 (ref 2.2~2.4) 다마스크장미꽃추출물 Tyrosinase효소 활성 억제(ref 2.5~2.6) 녹차추출물 Tyrosinase효소 활성 억제 (ref 2.7~2.9) 알로에베라잎추출물 주요 성분인 Aloesin은 Tyrosinase activity를 억제(ref 2.10~2.13)

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유기농 콤플렉스 화이트닝 (Organic Complex Whitening) INCI 명 Water, Glycerin, Azadirachta Indica Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Rosa Damascena Flower Extract, Camellia Sinensis Leaf Extract, Aloe Barbadensis Leaf Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata (Lichen) Extract 효능 (a) 유기농 콤플렉스 화이트닝 처리에 의한 세포독성 확인 결과 0.005% 0.016% 0.05% (b) 유기농 콤플렉스 화이트닝 처리에 의한 멜라닌컨텐츠 0.005% 0.016% 0.05% 마우스 유래 멜라노사이트 세포주에 유기농 콤플렉스 화이트닝을 처리한 결과 독성이 없음(a) 멜라닌 생성을 농도 의존적으로 억제함(b) 이러한 결과를 통하여 유기농 콤플렉스 화이트닝은 미백 효능이 있음이 확인됨

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유기농 콤플렉스 화이트닝 (Organic Complex Whitening) References 2. Whitening Effects. 2.1.Sharma K, Joshi N, Goyal C. Critical review of Ayurvedic Varṇya herbs and their tyrosinase inhibition effect. Ancient Science of Life. 2015;35(1):18-25. 2.2.Davis EC, Callender VD. Postinflammatory Hyperpigmentation: A Review of the Epidemiology, Clinical Features, and Treatment Options in Skin of Color. The Journal of clinical and aesthetic dermatology. 2010;3(7):20-31. 2.3.Amer M, Metwalli M. Topical liquiritin improves melasma. Int J Dermatol Apr;39(4): 2.4.Yokota T1, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res Dec;11(6): 2.5.Choi E-K, Guo H, Choi J-K, et al. Extraction conditions of white rose petals for the inhibition of enzymes related to skin aging. Laboratory Animal Research. 2015;31(3): 2.6.Cosmetic composition for skin whitening and wrinkle alleviation, containing, as active ingredients, white rose extract and gartanin derivative compound isolated therefrom. 2.7.No JK, Soung DY, Kim YJ, Shim KH, Jun YS, Rhee SH, Yokozawa T, Chung HY. Inhibition of tyrosinase by green tea components. Life Sci. 1999;65(21):PL241-6. 2.8.Mahmood T1, Akhtar N2. Skin Whitening Multiple Emulsions Loaded with Green Tea and Lotus Extracts: an Efficacy Study. Value Health Nov;18(7):A416. 2.9.Kim YC, Choi SY, Park EY. Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes. Journal of Veterinary Science. 2015;16(2): 2.10.Gunia-Krzyżak A, Popiół J, Marona H. Melanogenesis Inhibitors: Strategies for Searching for and Evaluation of Active Compounds. Curr Med Chem Jun 26. [Epub ahead of print] 2.11.Wang Z, Li X, Yang Z, He X, Tu J, Zhang T. Effects of aloesin on melanogenesis in pigmented skin equivalents. Int J Cosmet Sci Apr;30(2): 2.12.Yang ZQ, Wang ZH, Tu JB, Li P, Hu XY. [The effects of aloesin and arbutin on cultured melanocytes in a synergetic method]. Zhonghua Zheng Xing Wai Ke Za Zhi Sep;20(5): Chinese. 2.13.Jones K, Hughes J, Hong M, Jia Q, Orndorff S. Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Pigment Cell Res Oct;15(5):

7 (Organic Complex Anti-inflammation)
유기농 콤플렉스 안티인플라메이션 (Organic Complex Anti-inflammation) 유기농 콤플렉스 안티인플라메이션은 항염 작용을 통해 피부 내 염증을 억제하고 건강한 피부가 될 수 있도록 합니다 주요 성분 성분명 성분 효능 청호추출물 항염 효능(ref 3.1~3.3) 서양민들레잎추출물 대식세포주에서 염증 반응을 억제하는 효능(ref 3.4) 카렌둘라꽃추출물 항염 효능(ref 3.5~3.7) 캐모마일꽃추출물 아토피 피부의 개선 효능, 대식세포 알러지 모델에서도 효능, 또한 상처치유 효능 (ref 3.9~3.11) 은행잎추출물 피부염의 보호 효능, 만성적인 피부염증에도 효능(ref 3.14) 황금추출물 주요 물질인 baicalin은 피부염의 보호 효능, baicalein은 피부암을 억제(ref 3.15~18)

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유기농 콤플렉스 안티인플라메이션 (Organic Complex Anti-inflammation) INCI 명 Water, Glycerin, Artemisia Annua Extract, Taraxacum Officinale (Dandelion) Leaf Extract, Calendula Officinalis Flower Extract, Chamomilla Recutita (Matricaria) Flower Extract, Ginkgo Biloba Leaf Extract, Scutellaria Baicalensis Root Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata (Lichen) Extract 효능 (a) 유기농 콤플렉스 안티인플라메이션 처리에 의한 세포독성 확인 결과 0.005% 0.016% 0.05% (b) 유기농 콤플렉스 안티인플라메이션 처리에 의한 NO생성 확인 결과 0.005% 0.016% 0.05% LPS자극으로 염증을 유도한 마우스 대식세포주에 유기농 콤플렉스 안티인플라메이션을 처리한 결과 세포 독성에 영향을 미치지 않음(a) 농도 의존적으로 염증 생성 지표인 NO생성을 억제함(b) 이러한 결과를 통하여 유기농 콤플렉스 안티인플라메이션의 항염 효능이 있음이 확인됨

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유기농 콤플렉스 안티인플라메이션 (Organic Complex Anti-inflammation) References 3. Anti-inflammation Effects. 3.1.Li YJ, Guo Y, Yang Q1, Weng XG1, Yang L1, Wang YJ1, Chen Y1, Zhang D1, Li Q1, Liu XC1, Kan XX1, Chen X1, Zhu XX2, Kmoníèková E3, Zídek Z4. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol Aug 1;286(3):151-8. 3.2.Li T, Chen H, Wei N, Mei X, Zhang S, Liu DL, Gao Y, Bai SF, Liu XG, Zhou YX. Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity. Int Immunopharmacol Jan;12(1): 3.3.Melillo de Magalhães P1, Dupont I, Hendrickx A, Joly A, Raas T, Dessy S, Sergent T, Schneider YJ. Anti-inflammatory effect and modulation of cytochrome P450 activities by Artemisia annua tea infusions in human intestinal Caco-2 cells. Food Chem Sep 15;134(2): 3.4.Koh YJ, Cha DS, Ko JS, Park HJ, Choi HD. Anti-inflammatory effect of Taraxacum officinale leaves on lipopolysaccharide-induced inflammatory responses in RAW cells. J Med Food Aug;13(4):870-8. 3.5.Melillo de Magalhães P, Dupont I, Hendrickx A, Joly A, Raas T, Dessy S, Sergent T, Schneider YJ. Anti-inflammatory effect and modulation of cytochrome 3.6.Preethi KC, Kuttan G, Kuttan R. Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action. Indian J Exp Biol Feb;47(2): 3.7.Ukiya M, Akihisa T, Yasukawa K, Tokuda H, Suzuki T, Kimura Y. Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers. J Nat Prod Dec;69(12): 3.8.Lee SH, Heo Y, Kim YC. Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice. J Vet Sci Mar;11(1):35-41. 3.9.Chandrashekhar VM, Halagali KS, Nidavani RB, Shalavadi MH, Biradar BS, Biswas D, Muchchandi IS. Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model. J Ethnopharmacol Sep 1;137(1): 3.10.Martins MD, Marques MM, Bussadori SK, Martins MA, Pavesi VC, Mesquita-Ferrari RA, Fernandes KP. Comparative analysis between Chamomilla recutita and corticosteroids on wound healing. An in vitro and in vivo study. Phytother Res Feb;23(2):274-8. 3.11.Jarrahi M. An experimental study of the effects of Matricaria chamomilla extract on cutaneous burn wound healing in albino rats. Nat Prod Res Mar 20;22(5):422-7. 3.12.Yirmibesoglu E, Karahacioglu E, Kilic D, Lortlar N, Akbulut G, Omeroglu S. The protective effects of Ginkgo biloba extract (EGb-761) on radiation-induced dermatitis: an experimental study. Clin Exp Dermatol Jun;37(4): 3.13.Lim H, Son KH, Chang HW, Kang SS, Kim HP. Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol Pharm Bull. 2006 May;29(5): 3.14.Wang L, Shen T, Zhou CF, Yu JF, Zhu QX. [Changes of nitric oxide after trichloroethylene irritation in hairless mice skin and protection of ginkgo biloba extract and vitamin E]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi Apr;27(4): Chinese 3.15.Wu J, Li H, Li M. Effects of baicalin cream in two mouse models: 2,4-dinitrofluorobenzene-induced contact hypersensitivity and mouse tail test for psoriasis. Int J Clin Exp Med Feb 15;8(2): 3.16.Ma GZ, Liu CH, Wei B, Qiao J, Lu T, Wei HC, Chen HD, He CD. Baicalein inhibits DMBA/TPA-induced skin tumorigenesis in mice by modulating proliferation, apoptosis, and inflammation. Inflammation Apr;36(2): 3.17.Jung HS, Kim MH, Gwak NG, Im YS, Lee KY, Sohn Y, Choi H, Yang WM. Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro. J Ethnopharmacol May 7;141(1):345-9. 3.18.Kimura Y, Sumiyoshi M. Effects of various flavonoids isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. J Pharm Pharmacol Dec;63(12):