Acid Chlorides Using Thionyl Chloride

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1 Acid Chlorides Using Thionyl Chloride
The Conversion of tert-Butyl Esters to Acid Chlorides Using Thionyl Chloride 김은진 임동주 The Journal of Organic Chemistry February 14, 2017

2 Index Abstract Introduction Result and Discussion Conclusion Reference

3 Abstract

4 Introduction 카복실산 → 산 염화물 매커니즘

5 Introduction 카복실산 유도체의 상대적 반응성 유기 731쪽 그림 첫번째꺼

6 Introduction 카복실산 유도체의 상호변환

7 Optimization of tert-Butyl Ester to Acid Chloride Conditions
Result and Discussion Optimization of tert-Butyl Ester to Acid Chloride Conditions

8 Possible Mechanistic Pathways
Result and Discussion Possible Mechanistic Pathways

9 Ester Selectivity with Optimized tert-Butyl Ester Conditions
Result and Discussion Ester Selectivity with Optimized tert-Butyl Ester Conditions

10 Result and Discussion

11 Result and Discussion

12 Result and Discussion piv Fmoc Ts

13 Result and Discussion

14 Result and Discussion

15 Result and Discussion

16 Result and Discussion

17 Result and Discussion

18 Result and Discussion TMS TIPS TBS Bn

19 Result and Discussion piv Fmoc Ts

20 Result and Discussion

21 Conclusion 다양한 기질의 tert- 부틸 에스터를 산 염화물로 전환시키는 간단하고 효율적인 방법을 설명
반응이 산에 의해 촉진된다는 것을 시사하며, 경쟁 실험은 반응이 메틸, 1 °또는 2 °에스터 및 락톤의 존재하에 tert- 부틸 에스터에 대해 선택적임 알켄, 메틸 에터, 보호 된 아민, 설폰산 염, 탄산염 및 아세테이트 그룹을 비롯한 다른 작용기와 호환되며 산 염화물 합성에 일반적으로 사용되는 다른 방법의 대안을 제공

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