BPA variability of urinary BPA in Korean infants

Slides:



Advertisements
Similar presentations
동의 / 반대 ? “Professional athletes such as football or basketball players do not deserve the high salaries that they are paid. (2010/07/10 한국 ) 이용 가능한 template.
Advertisements

㈜ 에스엘에스컴퍼니 경영전략수립 Process 2013 년 11 월 대한상공회의소 중소기업경영자문단 정영수 자문위원.
신장이식 후 Cr-51 EDTA GFR 검사 결과의 분석 및 의의
Overview of recent observational study on vascular event and sodium
검출기 눈, 사진, Photoelectric device, Photomultipliers, Image intensifiers, Charged Coupled Device,
우울증 스트레스 불면증.
HBV DNA Viral Load Test 비교 COBAS TaqMan 48 과 COABS AmpliPrep 소개
Background  In the Helsinki policemen Study Hyperinsulinemia was associated with increased all-cause and CV mortality independent of other risk factors.
결혼 이민자 여성의 임신, 출산 지원과 건강보호를 위한 정책 과제
국제 저명인사 초청 멀티스케일 에너지 강좌 미래창조과학부 글로벌 프론티어 멀티스케일 에너지 시스템 연구단/서울대학교
Effectiveness of Recommendations to Prevent Reactivation of Latent Tuberculosis Infection in Patients Treated With Tumor Necrosis Factor Antagonists Loreto.
6.9 Redundant Structures and the Unit Load Method
Development and Initial Validation of Quality-of-Life Questionnaires for Intermittent Exotropia Ophthalmology 2010;117:163–168 Pf. 임혜빈 / R2 정병주.
Unit 4. Making Inferences
Journals & Conferences
Lecture 14 Term Structure of Interest Rates
<맞수–Chapter 2-9. 가정법 문제>
Keller: Stats for Mgmt & Econ, 7th Ed
Evaluation of Green roofs from the Water-Energy-Food Nexus perspective
Chapter 3 데이터와 신호 (Data and Signals).
한반도 정세와 동북아 안보.
기술 통계학 (Descriptive Statistics)
Excel과 통계학.
의료의 질 평가 분석 기법 김 민 경.
실습 (using SPSS) Department of Biostatistics, Samsung Biomedical Research Institute Samsung Medical Center.
강의실 변경: 과 424  과 B101 교재 : Quantitative Chemical Analysis
강의실 변경: 과 424  과 B101 교재 : Quantitative Chemical Analysis 
선형회귀분석.
소재제거 공정 (Material Removal Processes)
Progress Seminar 권순빈.
EPS Based Motion Recognition algorithm Comparison
알레르기 진단을 위한 UniCAP 검사 소개 이원의료재단 학술부.
CHAPTER 21 UNIVARIATE STATISTICS
Current clinical practice for cholecystectomy after ERCP
좋은 공학논문 작성을 위해서는 무엇이 필요한가?
제 14 장 거시경제학의 개관 PowerPoint® Slides by Can Erbil
1 도시차원의 쇠퇴실태와 경향 Trends and Features of Urban Decline in Korea
영유아 아토피피부염의 유발식품 항원과 임상 양상에 대한 실태조사
숭실대학교 마이닝연구실 김완섭 2009년 2월 8일 아이디어  - 상관분석에 대한 연구
Developmental Screening
Medical Instrumentation
4-1 Gaussian Distribution
PCA Lecture 9 주성분 분석 (PCA)
제 15 장 거시경제의 측정 PowerPoint® Slides by Can Erbil
사회복지프로그램 기획 및 평가 -로직모델을 중심으로 김유심(가양4종합사회복지관장) 프로그램의 개발과 평가의 개념
Modeling one measurement variable against another Regression analysis (회귀분석) Chapter 12.
화력발전소와 건강 이 종 태 고려대학교 환경보건학과
제4장 : 노동력 구조 1. 한국의 노동력 구조 2. 일본의 노동력구조 3. 유럽의 노동력 구조 4. 노동력 구조의 변화와 정책방향 동영상 학습과제 1. 노동력 구조와 의미는? 2. 각국의 노동력 구조를 조사하는 방법은? 3. 각국의 노동력 구조의 변화추이는? 4.
Inferences concerning two populations and paired comparisons
Association between two measurement variables Correlation
감마선스펙트럼 방사능측정 불확도 Environmental Metrology Center
: Two Sample Test - paired t-test - t-test - modified t-test
Statistical inference I (통계적 추론)
Mean and Variance.
The normal distribution (정규분포)
제 세 동.
사용자 경험 측정 (Measuring User Experience)
M P E G MPEG 1 Overview 제어인식연구실 이 찬 우 10월 19일 1998년.
제10장. 품질관리 (CHAPTER 10. Quality Control)
Modeling one measurement variable against another Regression analysis (회귀분석) Chapter 12.
Definitions (정의) Statistics란?
Bug Localization Based on Code Change Histories and Bug Reports
Hongik Univ. Software Engineering Laboratory Jin Hyub Lee
검출기 눈, 사진, Photoelectric device, Photomultipliers, Image intensifiers, Charged Coupled Device,
Progress Seminar 신희안.
Progress Seminar 이준녕.
Case of Epithelial Ingrowth After Cataract Surgery Treated with Argon Laser and Monitored by Fourier Domain Optical Coherence Tomography Jin Pyo Hong,MD1,
Progress Seminar 이준녕.
RISK POOLING.
Progress Seminar 이준녕.
Presentation transcript:

BPA variability of urinary BPA in Korean infants 논문초독회 BPA variability of urinary BPA in Korean infants 2017. 05. 30 이 장 우 2019-04-10

Long term variability and trend of urinary bisphenol A in Korean infants Highlights BPA is an endocrine disrupting chemicals that can affects the development of infants BPA was a substance with a short half-life and repeatedly exposed in the environment, but no information exists on variability of urinary BPA in infants Urinary BPA was the highest at birth, followed by 9, 12, 15 months and 3 months after birth. The intra-class correlation (ICC) of repeated measurements of BPA was low, ranging from zero (specific gravity and creatinine corrected) to 0.044 (uncorrected). The within variations mostly contributed in total variations of urinary BPA due to changes in urinary BPA by their growth and related various exposure. 2019-04-10

Summary - Objectives 영유아의 소변 중 BPA의 시기별 변화와 변동성 확인 - Sample collection 2019-04-10

Urinary BPA by age - Results Adjusted with gender, weight, height Corrected specific gravity 2019-04-10

- Results Intra-class coefficients (ICCs) and variance estimates of log transformed repeated measurements of BPA Variables   All Girls Boys N Variable estimate ICC Between- person σ2 Within- Unadjusted 320 0.075 1.611 0.044 150 0.124 1.423 0.080 170 0.054 1.781 0.029 SG adjusted 220 1.763 96 0.289 1.441 0.167 124 1.837 Cr adjusted 238 1.838 104 0.284 1.551 0.155 134 1.879 2019-04-10

- Disccusion 소변 중 BPA가 출생 시에 가장 높으며 3개월에는 낮아졌다가 9개월 부터는 다시 높아짐 출생 시 에는 엄마로부터 제대혈을 통해 전달 받았기 때문 그리고 양수를 통해 섭취 출생 후 3개월에는 분유, 모유 섭취 그리고 젖병, 장난감 등을 사용 그러나 아기 용품에 BPA 금지 및 대체물질 사용 그러므로 노출 수준이 낮음 9, 12, 15개월은 이유식과 다른 요인에 의해 높아짐 (다른 요인에는 실내환경 또는 아기의 활동 등) 2019-04-10

- Disccusion ICC 값이 0.044: within person variation이 더 기여함, 출생 시 데이터를 제외하더라도 ICC 값은 낮음 Between person variation이 0이므로 개인 간의 BPA의 수준의 차이를 구별할 수 없음 개인마다 Variation은 있으나 개인 간 차이는 크지 않음 이는 아이들의 사용 물품 또는 식이가 유사하기 때문 반복샘플의 수집 기간의 간격이 길다 (long term variability) 수집 기간의 간격이 클수록 ICC값이 낮아짐 2019-04-10

2019-04-10

Highlights Characterizing within- and between-individual variability of BPA concentrations is important for characterizing exposure in biomonitoring studies This has been investigated previously in adults, but not in children Concentrations ranged from 0.53 to 74.5 ng/ml, with geometric mean and standard deviation of 2.70 ng/ml and 2.94 ng/ml, respectively The between-individual variability was approximately equal to the within-individual variability (ICC = 0.51), and this ICC is somewhat higher than previously reported literature values Single spot samples obtained from young children provide a reliable characterization of absolute and relative exposure over the short time window studied, but this may not hold true over longer timeframes. 2019-04-10

- Results Number of repeated samples Table 2. Results for Spearman's rank correlation coefficient (ρ) between generated mean and observed 4-sample mean (average of 1000 iterations); and fraction correctly ranked by tertile based on ‘true’ 4-sample mean; 95% CI = 95% confidence interval Number of repeated samples ρ to observed 4-sample mean (95% CI) Fraction of subjects ranked in correct tertile based on observed 4-sample mean (95% CI) 1 0.81 (0.64–0.91) 0.68 (0.52–0.84) 2 0.88 (0.77–0.94) 0.76 (0.60–0.92) 3 0.91 (0.83–0.96) 0.80 (0.68–0.92) 4 0.93 (0.86–0.97) 0.84 (0.68–0.92) 2019-04-10

- Results Fig. 1. Within- and between person variation in urinary total BPA concentrations in 2–4 year old children. Horizontal bars denote 2-day arithmeticmean urinary concentration. Dashed line indicates estimated population 95th percentile for ages 2–4 years calculated based on data from a previous pooled study (see Heffernan et al., 2013); dot-dashed line indicates method limit of reporting. 2019-04-10

- Disccusion The relatively high ICC in the current study compared to previous Studies The majority of the previously published ICC values have been based on sampling in adults Mouthing behaviours - may increase the potential for buccal absorption Different patterns of food consumption - smaller but more frequent meals, more homogeneous diets Therefore, lower within-individual, within-day variation in BPA exposure and excretion rates and might expect between-day variation to be lower in infants 2019-04-10

- Disccusion Limitation The majority of the previously published ICC values have been based on sampling in adults Exposure classification (by goal) Extimating intake levels – within person variation should be considered Categorization of small children – between person variation should be considered Short term exposure - single spot sample may be appropriate Long term exposure - repeated samplingmay be required 2019-04-10

아이들의 쓰는 용품 및 식이가 크게 다르지 않기 때문에 개인간 변이가 낮음 그리고 개인내 변이는 큼 반감기가 빠르기 때문 차이점 Heffernan에서는 조금씩 자주 섭취하고 어른 보다 동일한 음식을 섭취하기 때문에 within individual, within-day variation이 낮음 아이들의 쓰는 용품 및 식이가 크게 다르지 않기 때문에 개인간 변이가 낮음 그리고 개인내 변이는 큼 반감기가 빠르기 때문 2019-04-10

2019-04-10

Highlights BPA is relatively stable during long-term freezer storage. The ability to measure BPA in urine samples after long-term storage could aid in studies of developmental effects in humans Our aims were to evaluate the stability of BPA in specimens after 22–24 years of storage and to measure within-person temporal variability in urinary BPA BPA levels had an inter-quartile range from 1.1 to 3.1 ng/mg creatinine, slightly higher than levels in specimens from NHANES The Spearman correlation was approximately 0.5 for samples 2 weeks apart and 0.3 for samples 4 weeks apart. BPA is relatively stable during long-term freezer storage. So, developmental effects of BPA exposure could be investigated with measurements from stored urine 2019-04-10

- Results 2019-04-10

- Results 2019-04-10

- Disccusion Our data show a correlation of over 0.5 for samples taken 2 weeks apart, which suggests that day-to-day exposures are similar in the short term. However, for samples taken 4 weeks apart, the correlation dropped to 0.3, suggesting that exposure becomes more variable across longer time intervals. The latter is the only one of these to report correlations between samples taken at various time intervals, and they also found decreased correlations as time between samples increased (maximum interval was 6 months) (Teitelbaum et al., 2008). 2019-04-10

보충자료 2019-04-10

2019-04-10

2019-04-10

2019-04-10

2019-04-10

Figure 1. Distribution of log-transformed (A) urinary BPA (ng/mL) and (B) creatinine-standardized BPA (μg BPA/g creatinine) concentrations in HOME Study children ages 1−8 years. p-values for child age trend <0.0001. Increases in urinary creatinine with age resulted in the more pronounced decrease in creatinine-standardized BPA concentrations (see Supporting Information Figure S1) 2019-04-10