연구 진행 상황 보고서 Insulin Pump CPF & BEPatch DBS & 안면자극 약물 주입 펌프 2주전 계획 연구 전달 임상시험 데이터 분석 시스템 개발 실험 진행 연구 결과 F/W 수정 Device 4대 제작 임상시험 진행 중 PLOS ONE 논문 Reject 문제점 및 대책 막힘 신호 검출 목표 및 계획 막힘 신호 JKMS 논문 제출
연구 진행 상황 보고서 AEP X-Project 2주전 계획 연구 결과 문제점 및 대책 목표 및 계획 실험 phase 3 진행 특허 내용 수정 후 출원 실험 phase 3 진행 Multi ch. Headset type device 제작 연구 결과 특허 사무소 방문 특허 내용 일부 수정 2ch. EEG & 1ch. ECG test board 제작 문제점 및 대책 목표 및 계획 특허 출원 2ch. EEG & 1ch. ECG version1 제작
Headset type EEG & ECG measurement device Example 1 Example 2 Example 3 Ref Ref Electrode location GND Ref1 Ref2 GND GND ACT1 ACT2 ACT1 ACT2 ACT1 Device concept 1) Right EEG 2) Left EEG 3) ECG 1) Right EEG 2) Left EEG 3) ECG 1) EEG 2) ECG Signal
2ch. EEG & 1ch. ECG Device summary Example 1 Active : L/R. Behind the ear, Ground : L. mastoid, Reference : Forehead 2ch. EEG : Active 1 – Reference & Active 2 – Reference 1ch. ECG : Active 1 – Active 2 ACT 1 + L. EEG Reference REF - ACT 2 + R. EEG Ground REF - Active 2 Active 1 ACT 1 + ECG ACT 2 -
2ch.EEG & 1ch.ECG System Test version 2ch. EEG & 1ch. ECG Bluetooth low energy Impedance measurement circuit 시험검사를 위한 protection IC 추가
2ch.EEG & 1ch.ECG System Board specifications check list Check list Test version Version 1 (working mockup) Noise level (Vrms) O 신호 측정 여부 – EEG 신호 측정 여부 – ECG Skin-electrode impedance measure Amplification Dynamic range (Input referred) Power consumption @active mode Weight Dimension
Impedance measurement 2ch.EEG & 1ch.ECG System Block diagram Li-polymer 1cell 105mAh Switch ON 3V linear regulator 1.8V linear regulator OFF Micro USB B type Battery charge controller Switching regulator (-3V) -1.8V linear regulator ACT1 ADC INA HPF LPF MCU Bluetooth 4.0 REF ACT2 Electrode INA HPF LPF REF SPI UART ACT1 INA HPF LPF ACT2 PWM ADC Skin-electrode Impedance measurement
2ch.EEG & 1ch.ECG System Noise level Electrode short test Reference – X-project device version1.2 = 0.11μVrms Test # Ch.1 Ch.2 Ch.3 1 0.1127 0.1167 0.1083 2 0.1142 0.1128 0.1081 3 0.1102 0.1068 0.1101 Average 0.1123 0.1121 0.1088
2ch.EEG & 1ch.ECG System Example 1 신호측정 Protocol 20s (eye open) – 20s (eye closed) – 20s (eye open) – 20s (eye closed) 1) ECG, 2) Left EEG, 3) Right EEG 측정 Device : test version Electrode position : active.1 (left mastoid), active.2 (right mastoid), ground (right behind the ear), reference (forehead) Test location : 융합관 324호 내자리 Electrode impedance : w/ skin preparation Electrode : snap type Ref GND ACT1 ACT2
2ch.EEG & 1ch.ECG System 신호 ECG L.EEG R.EEG ECG L.EEG R.EEG
2ch.EEG & 1ch.ECG System EEG FFT 결과 L.EEG R.EEG
2ch.EEG & 1ch.ECG System Example 2 신호측정 Protocol 20s (eye open) – 20s (eye closed) – 20s (eye open) – 20s (eye closed) 1) ECG, 2) Left EEG, 3) Right EEG 측정 Device : test version Electrode position : active.1 (left mastoid), active.2 (right mastoid), ground (right behind the ear), reference (forehead) Test location : 융합관 324호 내자리 Electrode impedance : w/ skin preparation Electrode : snap type Ref1 Ref2 GND ACT1 ACT2
2ch.EEG & 1ch.ECG System 신호 ECG L.EEG R.EEG ECG L.EEG R.EEG
2ch.EEG & 1ch.ECG System EEG FFT 결과 R.EEG
EEG & ECG lead summary Case 1 Case 2 Case 3 ACT REF REF REF ACT ACT ECG > EEG EEG > ECG
2ch.EEG & 1ch.ECG System ① ② ③ Impedance measurement block diagram C B Ref : Skin-Electrode Impedance and Its Effect on Recording Cardiac Potentials MUX ACT 1 C INA REF Vb-c ACT 1 B INA ACT 2 Va-b REF R ① ② ③ 30Hz PWM 1-LPF 16Hz 1-HPF 8Hz A ① ② ③
2ch.EEG & 1ch.ECG System Impedance measurement test Grass impedance meter와 비교