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Rhodopsin
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Rhodopsin Chromoprotein (Carotinoid+Protein)
눈의 망막에 있는 막대 모양의 간상세포에 함유되어 있는, 붉은색 빛을 감지하는 단백질이다.
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Components Opsin a membrane-bound G protein-coupled photo-receptor
Retinal a light-sensitive derivative of vitamin A 11-cis retinal → all-trans retinal
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Function Bleaching : Rhodopsin → Opsin+Retinal+Energy 최대흡광도 약 500nm
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Structure (1/2) 348 amino residues 55..306 Transmembrane receptor
Disulfide bond(110,187)
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Structure (2/2) Palmitoylation site 322, 323
Phosphorylation site 334, 336, 338, 340, 343 Dephosphorylation site 334, 338, 343
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Palmitoylation is the covalent attachment of fatty acids, such as palmitic acid, to cysteine residues of membrane proteins. → Hydrophobicity, membrane association Phosphorylation is the addition of a phosphate (PO4) group to a protein. → Switch ‘on’ or ‘off’
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Sequence
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Reference http://www.ncbi.nlm.nih.gov/
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