Orlistat.

Presentation on theme: "Orlistat."— Presentation transcript:

1 orlistat

2 contents Orlistat CLASSIFICATION Fat - Lipase moa Sar synthesis
- digestion and absorption pathway moa Sar synthesis 우리기민이 아주 잘하고있어요 상을 줘야겠어요ㅋㅋㅋㅋ 무슨 상을 줄까? 입술상이 딱이군!!!!!!

3 orlistat 화학명 비만 치료제 상품명 개발회사
N-Formyl-L-leucine[2S-[2alpha(R),3.beta]]-1-[[3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester 비만 치료제 Gastric and pancreatic lipase inhibitor로서 lipase의 활성부위에 결합하여 효소의 작용을 방해 dietary fat이 triglyceride와 fatty acid으로 분해되는 것을 억제하여 비만을 치료 상품명 Xenical 개발회사 Hoffmann-La Roche

4 classification 식용 억제제 소화 억제제 열생성 억제제 - 중추신경계에 작용
(중추성 아드레날린 수용체 흥분, 세로토닌 재흡수 억제) 소화 억제제 - 위장에 작용하여 흡수 저해 (지방분해 효소 억제제, 디사카리데이즈 억제제 등) 열생성 억제제 - 신체 대사율을 촉진하여 칼로리 소비 증가

5 lipase

6 Fat digestion and absorption pathway

7 Mechanism of action

8 sar

9 Retro synthesis Functional parts
- One portion of the channel determines its ion selectivity - Another portion of the channel serves as a gate - A single transmembrane domain is shown as the voltage sensor that operates the gate At a resting membrane potential, the channel is closed Then should any factor depolarize the membrane potential sufficiently, the voltage sensor moves outward and the gate opens

10 synthesis Functional parts
- One portion of the channel determines its ion selectivity - Another portion of the channel serves as a gate - A single transmembrane domain is shown as the voltage sensor that operates the gate At a resting membrane potential, the channel is closed Then should any factor depolarize the membrane potential sufficiently, the voltage sensor moves outward and the gate opens

11 synthesis Functional parts
- One portion of the channel determines its ion selectivity - Another portion of the channel serves as a gate - A single transmembrane domain is shown as the voltage sensor that operates the gate At a resting membrane potential, the channel is closed Then should any factor depolarize the membrane potential sufficiently, the voltage sensor moves outward and the gate opens

12 synthesis Acarbose Miglitol / Volibose Inhibit glycoside hydrolases
Higher efficacy than voglibose Miglitol / Volibose Voglibose is the newest - less side effect - economical

13 synthesis Acarbose Miglitol / Volibose Inhibit glycoside hydrolases
Higher efficacy than voglibose Miglitol / Volibose Voglibose is the newest - less side effect - economical

14 synthesis