연구 진행 상황 보고서 Insulin Pump CPF & BEPatch DBS & 안면자극 약물 주입 펌프 2주전 계획 연구

Presentation on theme: "연구 진행 상황 보고서 Insulin Pump CPF & BEPatch DBS & 안면자극 약물 주입 펌프 2주전 계획 연구"— Presentation transcript:

1 연구 진행 상황 보고서 Insulin Pump CPF & BEPatch DBS & 안면자극 약물 주입 펌프 2주전 계획 연구
전달 임상시험 데이터 분석 시스템 개발 실험 진행 연구 결과 F/W 수정 Device 4대 제작 임상시험 진행 중 PLOS ONE 논문 Reject 문제점 및 대책 막힘 신호 검출 목표 및 계획 막힘 신호 JKMS 논문 제출

2 연구 진행 상황 보고서 AEP X-Project 2주전 계획 연구 결과 문제점 및 대책 목표 및 계획 실험 phase 3 진행
특허 내용 수정 후 출원 실험 phase 3 진행 Multi ch. Headset type device 제작 연구 결과 특허 사무소 방문  특허 내용 일부 수정 2ch. EEG & 1ch. ECG test board 제작 문제점 및 대책 목표 및 계획 특허 출원 2ch. EEG & 1ch. ECG version1 제작

3 Headset type EEG & ECG measurement device
Example 1 Example 2 Example 3 Ref Ref Electrode location GND Ref1 Ref2 GND GND ACT1 ACT2 ACT1 ACT2 ACT1 Device concept 1) Right EEG 2) Left EEG 3) ECG 1) Right EEG 2) Left EEG 3) ECG 1) EEG 2) ECG Signal

4 2ch. EEG & 1ch. ECG Device summary
Example 1 Active : L/R. Behind the ear, Ground : L. mastoid, Reference : Forehead 2ch. EEG : Active 1 – Reference & Active 2 – Reference 1ch. ECG : Active 1 – Active 2 ACT 1 + L. EEG Reference REF - ACT 2 + R. EEG Ground REF - Active 2 Active 1 ACT 1 + ECG ACT 2 -

5 2ch.EEG & 1ch.ECG System Test version 2ch. EEG & 1ch. ECG
Bluetooth low energy Impedance measurement circuit 시험검사를 위한 protection IC 추가

6 2ch.EEG & 1ch.ECG System Board specifications check list Check list
Test version Version 1 (working mockup) Noise level (Vrms) O 신호 측정 여부 – EEG 신호 측정 여부 – ECG Skin-electrode impedance measure Amplification Dynamic range (Input referred) Power mode Weight Dimension

7 Impedance measurement
2ch.EEG & 1ch.ECG System Block diagram Li-polymer 1cell 105mAh Switch ON 3V linear regulator 1.8V linear regulator OFF Micro USB B type Battery charge controller Switching regulator (-3V) -1.8V linear regulator ACT1 ADC INA HPF LPF MCU Bluetooth 4.0 REF ACT2 Electrode INA HPF LPF REF SPI UART ACT1 INA HPF LPF ACT2 PWM ADC Skin-electrode Impedance measurement

8 2ch.EEG & 1ch.ECG System Noise level Electrode short test
Reference – X-project device version1.2 = 0.11μVrms Test # Ch.1 Ch.2 Ch.3 1 0.1127 0.1167 0.1083 2 0.1142 0.1128 0.1081 3 0.1102 0.1068 0.1101 Average 0.1123 0.1121 0.1088

9 2ch.EEG & 1ch.ECG System Example 1 신호측정 Protocol
20s (eye open) – 20s (eye closed) – 20s (eye open) – 20s (eye closed) 1) ECG, 2) Left EEG, 3) Right EEG 측정 Device : test version Electrode position : active.1 (left mastoid), active.2 (right mastoid), ground (right behind the ear), reference (forehead) Test location : 융합관 324호 내자리 Electrode impedance : w/ skin preparation Electrode : snap type Ref GND ACT1 ACT2

10 2ch.EEG & 1ch.ECG System 신호 ECG L.EEG R.EEG ECG L.EEG R.EEG

11 2ch.EEG & 1ch.ECG System EEG FFT 결과 L.EEG R.EEG

12 2ch.EEG & 1ch.ECG System Example 2 신호측정 Protocol
20s (eye open) – 20s (eye closed) – 20s (eye open) – 20s (eye closed) 1) ECG, 2) Left EEG, 3) Right EEG 측정 Device : test version Electrode position : active.1 (left mastoid), active.2 (right mastoid), ground (right behind the ear), reference (forehead) Test location : 융합관 324호 내자리 Electrode impedance : w/ skin preparation Electrode : snap type Ref1 Ref2 GND ACT1 ACT2

13 2ch.EEG & 1ch.ECG System 신호 ECG L.EEG R.EEG ECG L.EEG R.EEG

14 2ch.EEG & 1ch.ECG System EEG FFT 결과 R.EEG

15 EEG & ECG lead summary Case 1 Case 2 Case 3 ACT REF REF REF ACT ACT
ECG > EEG EEG > ECG

16 2ch.EEG & 1ch.ECG System ① ② ③ Impedance measurement block diagram C B
Ref : Skin-Electrode Impedance and Its Effect on Recording Cardiac Potentials MUX ACT 1 C INA REF Vb-c ACT 1 B INA ACT 2 Va-b REF R ① ② ③ 30Hz PWM 1-LPF 16Hz 1-HPF 8Hz A ① ② ③

17 2ch.EEG & 1ch.ECG System Impedance measurement test
Grass impedance meter와 비교