Rhodopsin
Rhodopsin Chromoprotein (Carotinoid+Protein) 눈의 망막에 있는 막대 모양의 간상세포에 함유되어 있는, 붉은색 빛을 감지하는 단백질이다.
Components Opsin a membrane-bound G protein-coupled photo-receptor Retinal a light-sensitive derivative of vitamin A 11-cis retinal → all-trans retinal
Function Bleaching : Rhodopsin → Opsin+Retinal+Energy 최대흡광도 약 500nm
Structure (1/2) 348 amino residues 55..306 Transmembrane receptor Disulfide bond(110,187)
Structure (2/2) Palmitoylation site 322, 323 Phosphorylation site 334, 336, 338, 340, 343 Dephosphorylation site 334, 338, 343
Palmitoylation is the covalent attachment of fatty acids, such as palmitic acid, to cysteine residues of membrane proteins. → Hydrophobicity, membrane association Phosphorylation is the addition of a phosphate (PO4) group to a protein. → Switch ‘on’ or ‘off’
Sequence
Reference http://www.ncbi.nlm.nih.gov/ http://www.ks.uiuc.edu/Research/rhodopsin/ http://en.wikipedia.org/wiki/Retinal