(Molecular Diagnostics and Mitochondrial Research Laboratory) 2012년 1분기 정리 화순전남대학교병원 미토콘드리아 연구실 (Molecular Diagnostics and       Mitochondrial Research Laboratory) 홈페이지- http://www.mtdna.or.kr 2012. 5. 3 (목)

Molecular Diagnostics and Mitochondrial research laboratory cell Nucleus Hematologic Malignancy Hematopoietic Stem cells Treatment Outcome MRD determination Biomarkers Aging: HSC, BM Environment New molecular Pathophysiology Potential new therapeutics Solid Organ Cancer Diagnosis Chronic Inflammatory/ Degenerative Diseases

정리 내용 연구원 동정 학술대회 참가 및 초록발표 Accepted manuscript 준비중인 SCI논문 연구과제 수행

2012년 mtDNA연구팀 실험실 동정 현재 신명근 교수님, 김혜란,김환영, 고정윤, Trang(창) 연구원 구성 2012. 02. 1 김지혜연구원 실험실 트레이닝 2012. 03. 1 김환영, 고정윤, Nguyen Thi Dai Trang 전남대학교 일반 대학원 석사과정 (분자의과학 협동과정) 입학 2012. 01.18 김환영 연구원 생일 2012. 02.08 2012 대한진단혈액학회 학술대회 (서울대학교 어린이병원) 최우수 연제상 수상 2012. 04. 08 엄하영 전임연구원 결혼 2012.04.28 KMMWP 1st Consensus Conference&2nd Research Meeting (화순전남대학교병원 대강당) 개최 2012. 05. 03 김혜란 박사 생일

2012 학술대회 참가 및 초록제출 1) 2012 대한진단혈액학회 학술대회(2012.02.08), 서울대학교 어린이병원 - New potential chemotherapeutic agents targeting prohibtib selectively killed AML cells in a mouse AML model - Benzopyrene exposure induced increase of mitochondrial mass and mitochondrial DNA copy number in blood cells and hematopoietic stem cells - Multiple Myeloma Panel: Dx Criteria, Risk Stratification&Response Criteria 2) 제 21차 대한 노인병학회 호남지회 연수강좌 (2012.02.11), 전남대학교 의과대학 덕재홀 ‘ 조기 암 스크리닝 최신 기법 ’ 3) 2012 Hwasun International Symposium on Genomics and Cell Therapy Joint Commemorative Symposium of Prof.Hwang's Retirement by KSPHO(2012.02.25), 광주 김대중 컨벤션 센터 ‘Recent Studies and Reports of Molecular Diagnostics in CNUHH Laboratory Medicine ’ 4) KHUPO 12th Annual International Proteomics Conference (2012.03.29),서울 대학교 ‘Use of MDLC-DIGE and LC-MS/MS to identify serum biomarkers for complete remission in patients with acute myeloid leukemia ’ 5) KMMWP 1st Consensus Conference&2nd Research Meeting(2012.04.28), 화순전남대학교병원 대강당 ‘Diagnostic panel & follow up panel for MM’

2012 Accepted manuscript 주저자 및 교신저자 Paroxysmal nocturnal hemoglobinuria-myelodysplastic syndrome associated with marked thrombocytosis and acquired clonal cytogenetic abnormality of t(3;12)(q28;q15). Leuk Lymphoma. 2012 Jan 31. [Epub ahead of print] HLA-A*02:07:02, a new allele identified by sequence-based typing in a Korean individual. Tissue Antigens. 2012 May;79(5):384-5. 3) Alteration of Mitochondrial Genome and its Pathophysiologial Role in Barrett’s Esophagus : Accept of PloS One 4) Association of allelic expression imbalance of JAK2 V617F mutation and phenotypic diversity in MPN: Major revision of AJP 5) Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer : Major revision of International Journal of Colorectal Disease

공저자 Unicentric Castleman Disease Relapsed After Rituximab-CHOP Chemotherapy or Radiation Therapy in an Adolescent. J Pediatr Hematol Oncol. 2012 Jan 16. [Epub ahead of print] An improved flow cytometry-based natural killer cytotoxicity assay involving calcein AM staining of effector cells. Ann Clin Lab Sci. 2012 Winter;42(1):42-9. Detection of HTLV-1 in the Labial Salivary Glands of Patients with Sjogren's Syndrome: A Distinct Clinical Subgroup? J Rheumatol. 2012 Apr;39(4):809-15. Interleukin-21 increases direct cytotoxicity and IFN-γ production of ex vivo expanded NK cells towards breast cancer cells. Anticancer Res. 2012 Mar;32(3):839-46. Dysfunction of Natural Killer T Cells in Patients with Active Mycobacterium tuberculosis Infection. Infect Immun. 2012 Mar 12. [Epub ahead of print] Detection of Amphotericin B Resistance in Candida haemulonii and Closely-Related Species Using the Etest, Vitek-2 Yeast Susceptibility System, and CLSI and EUCAST Broth Microdilution Methods. J Clin Microbiol. 2012 Mar 21. [Epub ahead of print]

2012 Manuscript preparation Association of allelic expression imbalance of JAK2 V617F mutation and phenotypic diversity in MPN: Blood resubmit 2) Prohibitin as a new biomarkers of leukemia for diagnosis, predicting prognosis, MRD monitoring and molecular therapeutics 4) The spectrum of mitochondrial genome instability in acute myeloid leukemia and leukemia stem cells The change of mtDNA sequence aberration, mtDNA content/mass, mtDNA copy number and clinical values in childhood leukemia 6) Clinical significance of mtDNA copy number in comparison with samples at Dx and F/U (initial remission or relapse) 7) Serum fibrin degradation product is a valuable tumor marker for multiple myeloma 8) Mitochondrial minisatellite alterations in single AML stem cells associated with vicious cycle hypothesis  9) Accuracy improvement for glucometer by reducing the hematocrit dependency using informatics technology 10) Mitochodrial Biomarkers for Benzopyrene Exposure

2012 연구과제 수행 한국연구재단 중견연구자사업 한국연구재단 해외우수연구소유치사업 한국연구재단 일반연구자사업 환경성 질환연구센터 3세부과제

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