Progress Seminar 2016.8.21 이준녕

연구 진행 상황 보고서 재활의학과 응급의학과 Bepatch/CPF 2주전 계획 연구 결과 문제점 및 대책 목표 및 계획 ABT 논문 투고 HW ver 2 firmware 개발 HW ver 2 혈압 실험 연구 결과 ABT 논문 투고 포멧 변경 재활의학과 요청 LabView 제작 Biological Sensor Optical Device 개발 Chemical sensor flow channel 개발 8/17일 미팅 센서 구매 진행 마취과 데이터 처리 진행 BCG for predicting AFib 논문 리뷰 BCG mechanism 논문 문제점 및 대책 WPR data 에러: 데이터 재정돈 필요, 및 데이터 처리 필요 CWA 센서 구매 진행 지연 마취과 데이터 정돈 필요 (소요시간 건당 약20분) 목표 및 계획 WPR 논문 데이터 재정돈 및 처리 혈압 시험

마취과 데이터: CI estimation CI is one of the factors affecting BP along with peripheral resistance, blood volume, and vessel elasticity. We have measurements of BP, and elasticity (PTT) Model parameters: PAT, HR, PPG amplitude, SBP, DBP Model targets: SBP, DBP, CI (cardiac index)

마취과 데이터: signals

BP vs CI (case 1)

PTT & Signals (case 1)

PTT & Signals (case 1) PPG amplitude follows BP Shifted CI follows BP

Models (case 1)

BP Models (case 1)

BP Models (case 1) Adding PPG amplitude significantly improves BP estimation

CI Models (case 1)

BP vs CI (case 2)

PTT & signals (case 2)

BP Models (case 2) In this case, neither PTT nor PPG amplitude contributes to BP estimation….

CI Models (case 2) In this case, adding the delay reduces correlation -> does BP affect CI or does CI affect BP?

논문: BCG mechanisms Full title: Ballistocardiogram: mechanism and potential for unobtrusive cardiovascular health monitoring Authors: CS Kim, SL Ober, MS McMurtry, BA Finegan, OT Inan, R Mukkamala, JO Hahn Journal: Nature Scientific Reports Published Date: 9 August 2016 Background: The source of BCG has not been clearly identified, this journal tries to model the BCG waveform based on physiological events in the aorta and verifies this model with experimental data

Modelling & Validation

논문: BCG mechanisms Assumptions: - Effect of Q is negligible as compared to BP - BCG mostly works in 1D from head to toe Approximations: - P0 estimated from P1 and PTT - Cross sectional area of aorta based on experimental average Interpretation of results: - timing between I-J peaks may represent aortic pulse transit time - J wave amplitudes may represent relative changes in the aortic PP which in turn is well correlated with changes in cardiac stroke volume Downside: BCG was not measured in these subjects