A Study on the Extraction and Efficacy of

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1 A Study on the Extraction and Efficacy of
Bioactive Compound from Hovenia dulics Thank you for chairperson. My name is jong kwan park. This study was carried out to synthesize of Fe-Si Alloy Nanoparticles by Gas Phase Reaction. Department of Chemical Engineering, Kongju National University, Kongju , Korea

2 생물자원 Hovenia dulcis √ Common Name : Raisin Tree √ Height : 10~17 m
√ Leaf : 8~15 cm - nonshowy to yellow fall color √ Fruit - reddish-brown drupe - 8 mm in diameter - sweet and can be eaten

3 추출조건 최적화 Effect of fruit, leaf and stem of hovenia dulcis
on decrease in alcohol concentration Effect of extraction times (reaction temp : 100℃, reaction time: 6hr)

4 생리활성 Mechanism The metabolism of ethanol
Effect of extract concentration of hovenia dulcis on enzyme activity

5 동물실험 결과 Effect of oral administration of extract on serum AST, ALT and LDH levels in rats at 24 hr after CCl4 and CCl4 + Hovenia dulcis extract injection 3000 2000 8000 2500 1600 6400 2000 1200 4800 AST(IU/L) ALT(IU/L) LDH(IU/L) 1500 800 3200 1000 500 400 1600 CCl4 CCl4+Extract CCl4 CCl4+Extract CCl4 CCl4+Extract Photomicrographs of rat liver Control CCl4 treated group CCl4 / extract treated group

6 생산성 향상 실험 결과 + Sugar 2N-HCl Acid Hydrolysis
Fig. 18 Effect of activity on pH (reaction temp.= 80℃, reaction time = 4 hr)

7 생물자원으로부터 기능성 물질의 탐색 및 동정 생물자원으로부터 기능성 물질(항암제, 항생제, 유용단백질, 생리활성물질 등)의 탐색 및 동정을 위하여 HPLC를 이용하여 대상물질을 순수 분리 및 정제하고, NMR과 MS 등을 사용하여 화학구조를 분석하며 또한 생리활성 확인을 위해 in vitro, in vivo 실험을 수행한다. 항암 활성물질 탐색 및 동정 유용 생물자원