Bacterial translocation
Bacteria and gut relationship 300-500 여종의 미생물 종이 존재 Fecal solid 의 60%rk bacteria
Normal gut flora Fermentation of non-digestible diets Short-chain fatty acids Vitamin K production Epithelial cell proliferation, differentiation Inhibition of pathogenic bacteria J G H 2007 22 464
Bacterial translocation Bacterial translocation (BT) the migration of bacteria or bacterial products from the intestinal lumen to mesenteric lymph nodes (MLNs) or other extraintestinal organs and sites BT in healthy individuals: 5 ~ 10% In cirrhotic patients: 40-100% Hepatology 2005;41:422
Spontaneous infection Hyperdynamic circulatory state SBP Spontaneous infection Bacteremia BT Ascites Hyperdynamic circulatory state Hepatorenal syndrome Hepatopulmonary syndrome
Mechanisms of bacterial translocation
Portal hypertension and BT Portal HTN Small bowel motility ↓ Intestinal bacterial overgrowth Mucosal permeability↑ Am J Gastroenterol 2003;98:1362 Am J Gastroenterol 2001;96:1251 Hepatology 2000;31:858
Bacterial translocation and circulatory effects Proinflammatory cytokines TNF-alpha, IL-1, Nitric oxide (NO)
Cochrane Database Syst Rev. 2009 Apr 15;(2):CD004791.
Cochrane Database Syst Rev. 2009 Apr 15;(2):CD004791.
Liver Int 2009;29:1189
Hyperdynamic circulatory state Portal HTN Varices BT Bleeding Renal failure Ascites BT Refractory BT BT SBP Sepsis Hyperdynamic circulatory state Increased renin, aldosterone, NO Increased cardiac output, vasodilatation, HVPG
노르플록사신 제제 식약청 허가 현황 제품명 제조(수입)회사명 연락처 뉴사달정 100㎎ (주)동구제약 02-2688-9611~5 종근당박시달정 (주)종근당 080-977-3380 종근당박시달캅셀 200㎎ 노로칸캡슐 200㎎ (주)하원제약 02-554-2012 노푸리신캅셀 200㎎ (주)한국알리코팜 02-585-0004 노플록신정 200㎎ (주)한국코러스제약 02-2632-4983 파마노르플록사신캡슐 200㎎ (주)한국파마 02-558-1277 유레카신캡슐 200㎎ 국제약품공업(주) 031-781-9081~9 노프린정 200㎎ 대한뉴팜(주) 02-581-2333 모아록신캅셀 200㎎ 동인당제약(주) 031-319-1990 보람노르플록사신캡슐 보람제약(주) 031-493-0077 후루스펙캡슐 200㎎ 케이엠에스제약(주) 031-215-5456 크라운노르플록사신캅셀 200㎎ 크라운제약(주) 031-443-3923