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Omeprazole 고수연.

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Presentation on theme: "Omeprazole 고수연."— Presentation transcript:

1 Omeprazole 고수연

2 위에서의 소화

3 위장관에 작용하는 약물 제산제 위산분비억제제 H2 receptor antagonist: cimetidine, rantidine, famotidine, nizatidine M1 selective antagonist: pirenzepine Proton pump inhibitor(PPI): omeprazole 점막보호약물 Sucralfate Prostaglandin: misoprostol

4 Mechanism of action

5 Omeprazole omeprazole 화학명
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole 분류 소화성 궤양 치료제, 위산분비 억제제 약리 Proton pump(H+/K+-ATPase) inhibitor(PPI) 적응증 위십이지장 궤양, 역류성 식도염, Zollinger-Ellison syndrome, Helicobacter 감염에 의한 소화성 궤양 상품명 Losec, Prelosec 개발사 AstraZeneca

6 Omeprazole activation

7 Effect of racemic omeprazole&enatiomer

8 Retrosynthesis

9 Synthesis

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